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Month: December 2016

More progress on huntingtin cryo-EM

Posted onDecember 19, 2016Leave a comment

I was over the moon last week to receive an update (available here) on the cryo-electron microscopy grid preparation from Dr Justin Deme, a post doc in Prof Susan Lea’s lab. Using the full-length huntingtin protein samples I prepared, Justin is preparing very small grids with the protein on them so that we can look Read More …

CategoriesData, General

Updates on huntingtin EM and domain construct test expression

Posted onDecember 5, 2016Leave a comment

Last week was all about big protein samples! I got an informative email update from Prof Susan Lea and Dr Justin Deme on the full-length huntingtin EM work (all 3144 amino acids) they are doing in Oxford. The grids are definitely getting better and hopefully we will have thin enough ice to do some serious Read More …

CategoriesGeneral

Recent Posts

  • Updates on all the huntingtin samples I have made and what has been keeping me busy in the lab
  • Purifications of HTT and HTT-HAP40 from insect (Sf9) and mammalian (EXPI293F) expression systems
  • Summer travels showcasing the huntingtin protein toolkit
  • Identifying new members of the huntingtin interactome with BioID and other updates
  • Successful generation of fragments of the HTT protein and improving the purification procedure for the HTT-HAP40 complex

Recent Comments

  • racheljaneharding on Identifying new members of the huntingtin interactome with BioID and other updates
  • Dee Farry on Identifying new members of the huntingtin interactome with BioID and other updates
  • J.B. Shaw on Searching far and wide for proteins that bind huntingtin
  • J.B. Shaw on SAXS of huntingtin – a different approach to assess the structure of this protein
  • J.B. Shaw on SAXS of huntingtin – a different approach to assess the structure of this protein

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  • About Lab Scribbles
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  • About Lab Scribbles
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