I was over the moon last week to receive an update (available here) on the cryo-electron microscopy grid preparation from Dr Justin Deme, a post doc in Prof Susan Lea’s lab. Using the full-length huntingtin protein samples I prepared, Justin is preparing very small grids with the protein on them so that we can look at them using an electron microscope. This method is very cool and cutting edge and allows us to image individual protein molecules and generate very detailed models of the protein atomic structure. Justin is making great progress on this and I am sure I will have more exciting news on this aspect project soon.

I have also been doing some more protein purification of both the full-length huntingtin protein as well as shorter constructs.

I am wrapping up for the holidays in the lab this week but will be posting any updates here soon!