Month: August 2017
Experiments on huntingtin interacting protein HMGB1
To improve the samples I am making of huntingtin for structural studies, I am trying to find binding partners of the huntingtin protein. Complexes of huntingtin with binding partners may be more stable and amenable to study by structural methods. HMGB1 is one such reported huntingtin interacting protein. I have now tried to make this Read More …
Cryo-EM updates and more!
This past few weeks have been busy with fellowship applications, writing grants and papers so I am rather behind on keeping you updated but there has been some exciting progress: Susan Lea has made fantastic progress processing cryo-EM data of our samples and we now have a 13 A envelope of the protein: https://zenodo.org/record/841824 2. On Read More …