We have generated some really interesting data from our cryo-EM studies of the huntingtin protein to date. Susan Lea and Justin Deme who are working on the HTT samples I send from Toronto, recently shared this screen capture of the huntingtin envelopes from the most recent sample which are super to see: As a complementary Read More …

Its been a busy few weeks as we have been preparing and then launching the new exciting open notebook project from the SGC. 12 early career researchers are joining me to open up their lab notebooks on their various projects and we kicked off the launch with a super meeting in Ottawa, supported by the CIHR Read More …

In my continued bid to find protein molecules which might bind and stabilize the huntingtin (HTT) protein molecule for my structural biology experiments, I have used a technique called pull-down to assess binding of the DNA binding protein HMGB1 as well as the HTT nanobody iVHH4 which I previously described and purified. In this case, Read More …