Communication
CHDI Meeting Malta 2017
This week I am in Malta having a really exciting time meeting lots of fellow Huntington’s disease scientists at the CHDI Therapeutics Conference. We have had lots of interesting talks on huntingtin structure/function, huntingtin lowering strategies, and biomarkers. You can read about the talks on the HDBuzz twitter feed @HDBuzzfeed This afternoon we have been Read More …
Back in the lab! Conferences, making proteins, electron microscopy and exciting collaborations
After a month’s hiatus from my last post I am back with lots of exciting news and updates. Multiple coinciding factors mean I haven’t been able to update you all as much as I would have liked but things are back on track in the run up to the holidays so I hope to have Read More …
Huntingtin linker sequence determination by computational methods – correspondence with Alex Holehouse
I firmly believe that the more scientists discuss their data with experts both within their field and outside of it, the better! Without peer review, constructive criticism and comprehensive evaluation of the data we all generate, we can not understand its limitations nor its value to others working in the same field. In this vein, Read More …
Ontario open access: accelerating science symposium
Today I am attending and giving a brief talk at the Ontario open access symposium hosted by University of Toronto. Loads of cool and innovative open access innovators and enablers are giving talks, the keynote is by John Willinsky, Stanford University. I’ll be live tweeting the day so follow the progress through my on @labscribbles Read More …
CHDI Meeting in Palm Springs – Thursday: Cell Replacement Technologies and Clinical Trial Data Analysis
The first session of the final day at the CHDI meeting focused on restoring neuronal networks. Most of these methodologies focus on the once fanciful idea that damaged neurons in the brain can be replaced with healthy new ones. Work by Ali Brivanlou using embryonic stem cells (cells which may be nurtured to grow into Read More …
CHDI Meeting in Palm Springs – Tuesday: Huntingtin Structure Function and the htt Gene and Genome
Tuesday hosted the session most closely related to my current focus of HD research – huntingtin structural biology and structural insights into HD pathology. Frederic Sandou presented some very interesting data from his EMBO publication regarding huntingtin proteolysis in cells. The C-terminal fragments generated by cutting huntingtin appear to be toxic to cells and this Read More …
CHDI Meeting Palm Springs – Monday: Discussions and Introductions
The conference kicked off yesterday at the Parker Hotel, Palm Springs. 300 participants from a range of backgrounds, clinicians through to computational modellers, gathered to share research achievements and discuss new areas of interest in the field of HD. Following a series of updates from CHDI staff in preclinical biology and chemistry HD research as Read More …
CHDI Meeting in Palm Springs – Sunshine and Science!
I have flown to Palm Springs this week to attend the CHDI Annual Conference. Academics, clinicians and industry scientists funded or working in collaboration with the CHDI Foundation meet here every year to discuss the latest work and breakthroughs in the field of Huntington’s disease. I am looking forward to hearing updates from the latest Read More …
Protein structure function
I would like to explain a bit about the experiments I am doing and their relevance to HD research. Not everyone is a protein biochemist (its a pretty niche skill set) so I hope this primer allows you to get a bit more of an idea about the kind of work I am attempting with Read More …